Pregnancy Cat

No adequate well-controlled studies of safety for pregnancy. Limited data suggest that clomipramine is likely to be excreted in human breast milk. Although it has known risk of damage to fetus.

Precautions

Talk to your doctor or pharmacist before taking Clomipramine if you:

have ever had suicidal thoughts
suffer from epilepsy (fits)
have had a head injury or have suffered brain damage
are going to have electric shock therapy (ECT)
have other problems with your heart
have been told you have a low level of potassium in your blood (hypokalaemia). The doctor will need to treat this before you start taking clomipramine
have kidney disease
suffer from schizophrenia or other mental health conditions
have a blood disorder
have an overactive thyroid gland
have had severe constipation for a long time
have a tumour (cancer) of the adrenal gland (such as phaeochromocytoma or neuroblastoma)
liver disease
have low blood pressure
wear contact lenses

Overdose Effects

It has been reported that adults can experience dryness of mouth, dilated pupils, coma, convulsions. Tachycardia/ cardiac arrhythmia, respiratory depression and alteration in blood pressure are noted.

Drug Classes

Tricyclic & related anti-depressant drugs

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

Composition

n/a

Mode Of Action

Clomipramine Hydrochloride is an original tricyclic antidepressant, a member of the dibenzazepine group of compounds. It is presumed to influence obsessive and compulsive behaviors through it's effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown but it has the capacity to inhibit the reuptake of serotonin (5-HT) which is thought to be important (like obsessions, compulsion) thus hampers social acquaintance.

Reconstitution

n/a