Cipran Capsule (Extended Release)
In-house product
Offer
Indications
Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of Major Depressive Disorder (MDD) in adults.Limitation of Use: Levomilnacipran is not approved for the management of fibromyalgia. The efficacy and safety of Levomilnacipran for the management of fibromyalgia have not been established.
Interaction
Strong CYP3A4 inhibitors such as ketoconazole: Do not exceed 80 mg once daily.
Contraindications
Hypersensitivity to levomilnacipran, milnacipran HCl or to any excipient in the formulation.The use of MAOIs intended to treat psychiatric disorders with Levomilnacipran or within 7 days of stopping treatment with Levomilnacipran is contraindicated because of an increased risk of serotonin syndrome. The use of Levomilnacipran within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated.Starting Levomilnacipran in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome.
Side Effects
Hypersensitivity
Suicidal Thoughts and Behaviors in Adolescents and Young Adults
Serotonin Syndrome
Elevated Blood Pressure
Elevated Heart Rate
Increased Risk of Bleeding
Angle Closure Glaucoma
Urinary Hesitation or Retention
Activation of Mania/Hypomania
Seizure
Discontinuation Syndrome
Hyponatremia
Dosage
Recommended dose: 40 mg to 120 mg once daily with or without food. Initiate dose at 20 mg once daily for 2 days and then increase to 40 mg once daily. Based on efficacy and tolerability, increase dose in increments of 40 mg at intervals of 2 or more days. The maximum recommended dose is 120 mg once daily. Take capsules whole; do not open, chew or crush.Renal Impairment: Do not exceed 80 mg once daily for moderate impairment. Do not exceed 40 mg once daily for severe renal impairment.Discontinuation: Reduce dose gradually whenever possible.
Administration
n/a
Pregnancy Cat
Pregnancy: Third trimester use may increase risk for symptoms of poor adaptation (respiratory distress, temperature instability, feeding difficulty, hypotonia, tremor, irritability) in the neonate.
Precautions
n/a
Overdose Effects
n/a
Drug Classes
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Composition
n/a
Mode Of Action
The exact mechanism of the antidepressant action of levomilnacipran is unknown, but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of reuptake at serotonin and norepinephrine transporters. Non-clinical studies have shown that levomilnacipran is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI).Levomilnacipran binds with high affinity to the human serotonin (5-HT) and norepinephrine (NE) transporters (Ki = 11 and 91 nM, respectively) and potently inhibits 5-HT and NE reuptake (IC50 = 16-19 and 11 nM, respectively). Levomilnacipran lacks significant affinity for any other receptors, ion channels or transporters tested in vitro, including serotonergic (5HT1-7), α- and β-adrenergic, muscarinic, or histaminergic receptors and Ca2+, Na+, K+ or Cl- channels. Levomilnacipran did not inhibit monoamine oxidase (MAO).
Reconstitution
n/a
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