Pregnancy Cat

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Precautions

Skin test should be done before initiating therapy. Heart failure; renal impairment. Pregnancy, lactation, childn.

Overdose Effects

Symptoms: Flushing, nausea, vomiting and dizziness. Management: Symptomatic and supportive treatment.

Drug Classes

Hormone in bone formation by Inhibiting bone resorption

Storage Conditions

Store between 2-8° C.

Composition

Each ml Salmon Calcitonin injection contains-

50 or 100 I.U. salcatonin (present as Polyacetate polyhydrate)
Sodium acetate 0.2%
Glacial acetic acid 0.2%
Sodium chloride 0.75%

Salmon Calcitonin contains 32 amino-acids in linear sequence with a disulphide bridge at position 1 and 7 and a molecular weight of 3431.9 (free peptide). Salcatonin is a white or grey-tinged white amorphous powder. It is very soluble in water and very slightly soluble in alcohol.

Mode Of Action

Calcitonin is a polypeptide hormone produced by the ultimobranchial gland in non-mammalian vertebrates or by the mammalian thyroid parafollicular cells. It inhibits osteoclastic bone resorption and reduces bone turnover. It decreases tubular reabsorption and promotes renal excretion of Ca, Cl, Na, Mg, K and phosphate.

Reconstitution

n/a