Oxyton DS IM/IV Injection

Strength
10 IU/ml

Generic
Oxytocin

(0 reviews)

Product Inquiry

Add to wishlist Add to compare

Brand
Renata Limited

In-house product

Price

৳25.69 /pc

Quantity

(100 available)

Cashback

80

For Purchasing 3000 BDT+

Cashback

100 BDT

For Purchasing 4500 BDT+

Alternative Products

Essentials Dosage & Administration Description

Indications

Oxytocin is indicated in-

Induction of labor, stimulation of uterine contractions.
Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta.
To stimulate lactation, only it advised by the registered Gynaecologist/Physician.
Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage.

Interaction

Severe hypertension has been reported when Oxytocin was given three to four hours following prophylactic administration of a vasoconstrictor in conjunction with caudal-block anesthesia. Cyclopropane anesthesia may modify Oxytocin’s cardiovascular effects, so as to produce unexpected results such as hypotension. Maternal sinus bradycardia with abnormal atrioventricular rhythms has also been noted when Oxytocin was used concomitantly with cyclopropane anesthesia.

Contraindications

Cephalo-pelvic disproportion.
Abnormal position of the child or abnormal position of the skull.
Overdistention of the inferior segment of the uterus.
Severe toxaemia.
Hypertonic uterine dysfunction.
Foetal distress, where delivery is not imminent (uterine contractions may increase hypoxia).
Cord presentation and prolapse.
Total placenta previa.
Vasa praevia.

Side Effects

Hypersensitivity to the drug may result in uterine hypertonicity, spasm, titanic contraction or rupture of the uterus.
The possibility of increased blood loss and afbrinigenemia should be kept in mind when administering the drug.
Severe water intoxication with convulsions and coma has occurred.
Oxytocin may occasionally cause nausea, vomiting, haemorrhage or cardiac arrhythmias, anaphylactic reaction.

Adverse reactions: Exceptionally, symptoms of water intoxication may occur. An increased incidence of icterus neonatorum has been reported after use of oxytocin.

Dosage

Induction of labor, stimulation of uterine contractions: Oxytocin should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml of infusion fluid. The administration is started at 1 mU (1 mU=0.001 IU) per minute. According to the effect obtained the dosage can be doubled every 30-45 minutes until the uterus threshold has been attained. A further increase will then usually provide optimal activity. The threshold is generally below 10 mU per minute.N.B.: Intramuscular administration of Oxytocin may lead to an irregular response and symptoms of overdosage. It intramuscular administration is nevertheless unavoidable, dosage should not exceed 0.5-1 IU per injection. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta: Intramuscular injection of 2-5 IU, or as intravenous infusion in an adequate dosage To stimulate lactation, only it advised by the registered Gynaecologist/Physician: Intramuscular injection of 2 IU Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage: Intramuscular injection of 2-5 IU every 30-60 minutes or as intravenous infusion in an adequate dosage

Administration

n/a

Pregnancy Cat

Pregnancy category C. It is not known whether Oxytocin is excreted in human milk

Precautions

Since uterine sensitivity to oxytocin may vary widely. Oxytocin should be used with care. The smallest effective dose must be determined for each patient and then utilized to initiate labor.
Oxytocin should only be used when adequate medical supervision is provided. Fetal heart rate and maternal blood pressure should be determined.
Oxytocin should be used with care if scars of the uterus and of the cervix uteri exist.

Overdose Effects

Excess oxytocin may cause violent uterine contractions leading to fetal bradycardia and arrhythmias, extensive laceration of the soft tissues, uterine rupture and perhaps fetal or maternal death. Treatment consists of immediate discontinuation of the infusion and induction of tocolysis.

Drug Classes

Drugs acting on the Uterus

Storage Conditions

Store in between 2 to 8°C, in dark & frost free place. Keep out of the reach of children.

Composition

n/a

Mode Of Action

Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase. Oxytocin has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Reconstitution

Oxytocin has been shown not to lose its potency for at least 24 hours (at room temperature and in daylight conditions) when diluted with one of the following infusion fluids:

Sodium chloride 0.9%
Anhydrous glucose 5%

With these infusion fluids, Oxytocin can also be injected directly into the infusion line without causing precipitation of the ingredients.Direct injection into the infusion line is also possible with the following infusion fluids, provided that there are no contra-indications of perfusion of the Individual fluids.

Sorbitol 5%
Invert sugar 10%
Ringer's solution
Hartmann's solution (Ringer-lactate);
Rheomacrodex
Vamin

However, in the later fluids the 24-hours stability has not been established

Frequently Bought Products

Reviews & Ratings

0 out of 5.0

(0 reviews)

Rate this Product

There have been no reviews for this product yet.